Mahandranauth A. Chetram
Department: Biological Sciences
Year of Study: 2nd year Ph.D. Student
Mentor: Dr. Cimona V. Hinton, Assistant
Professor of Biology
January 2009 – Present, Research Assistant/Graduate Student Clark Atlanta University, Atlanta, GA
Project one: Loss of PTEN permits CXCR4-mediated tumorigenesis through the ERK1/2 in prostate cancer cell.
Project two: ROS induces CXCR4/SDF1α autocrine and intracrine signaling in prostate cancer cells.
June 2005 – December 2007,
Undergraduate Research Assistant,
University of Nebraska, Lincoln, NE
Project one: Studied the effects of phosphatidylinositol 5-phosphate on root growth in wild type and atx1 (Arabidopsis Trithorax Homologue) mutant, Arabidopsis plants.
Project two: Investigate the cellular localization of Xyloglucan Endotransglycosylase/Hydrolases 33 (XTH33) (a cell wall modifying gene) and also to identification the transcription regulation mechanism that exists, between the ATX1 and XTH33 gene in Arabidopsis.
Mahandranauth A. Chetram, Valerie Odero-Marah and Cimona V. Hinton. Loss of PTEN Permits CXCR4- mediated Tumorigenesis through ERK 1/2 in Prostate Cancer Cells. Molecular Cancer Research 2010. Under review.
Ivan Ndamukong, Anand Chetram, Adbelaty Saleh, Zoya Avramova. Wall-Modifying Genes Regulated by the Arabidopsis Homolog of Trithorax, ATX1; Repression of the XTH33 gene as a test case. The Plant Journal 58(4): 541-553 (2009).
Mahandranauth A. Chetram, Cimona V. Hinton (2010) “The regulatory role of PTEN in CXCR4-mediated metastasis of prostate cancer cells” CCRTD-Prostate Cancer Symposium, Atlanta GA.
Mahandranauth A. Chetram, Cimona V. Hinton (2010) “Loss of PTEN Permits CXCR4-mediated Metastasis through the ERK1/2 Pathway in Prostate Cancer Cells” Joint MRS-AACR Conference on Metastasis and the Tumor Microenvironment, Philadelphia, PA. Click here to link to the abstract.
Mahandranauth A. Chetram, Cimona V. Hinton (2010) “Decreased expression of PTEN enhances CXCR4-mediated proliferation and tumorigenesis in prostate cancer cells” AACR- conference, Washington DC. Click here to link to the abstract.
Mahandranauth A. Chetram, Cimona V. Hinton (2010) “Down regulation of PTEN is observed in CXCR4 expressing prostate cancer cells” CCRTD-Prostate Cancer Symposium, Atlanta GA.
Mahandranauth A. Chetram, Cimona V. Hinton (2009) “Down regulation of PTEN is observed in CXCR4 expressing prostate cancer cells” ABRMS - conference, Phoenix AZ. Click here to link to the abstract.
Mahandranauth A. Chetram, Zoya Avramova (2007) “Effects of phosphatidylinositol 5-phosphate on root growth in wild type and atx1” UCARE- conference, Lincoln NE.
Brittany T. Jones, Mahandranauth A. Chetram and Cimona V. Hinton (2010) “Expression of PTEN in CXCR4-Overexpressing Cells Alters Morphology of Prostate Cancer Cells” Minority Serving Research Institutions Partnership Consortium (MSIRPC) Conference, Baltimore, MD.
T’Shane C. Williams, Amber L. Taylor, Mahandranauth A. Chetram and Cimona V. Hinton (2010) “Inhibition of CXCR4-Mediated Prostate Bone Metastasis by the Tumor Suppressor PTEN” CCRTD-Prostate Cancer Symposium, Atlanta GA.
Previous Degree Obtained:
University of Nebraska, B.S., Biochemistry, August 2007
RISE Scholar, 2008-present
University of Nebraska Undergraduate Creative Activity Research Experience (UCARE) Scholar, 2006- 2007
Career Aspirations and Goals:
My immediate career goal is to graduate with my Ph.D. so as to persue a post-doctoral position in cancer biology. Eventually, I hope to transition into a faculty position that focuses on cancer research. Furthermore, my lifelong purpose is to contribute to the advance of the human race by overcoming cancer.